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KMID : 0387420060170020075
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Korean Society of Oriental Neuropsychiatry
2006 Volume.17 No. 2 p.75 ~ p.89
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The Effects of Rhododendron simsii Planch(RSP) on the Alzheimer’s Disease Model
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Jang Jin-Sil
Lee Sang-Ryong
Jung In-Chul
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Abstract
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Objective: This experiment was designed to investigate the effect of Rhododendron simsii Planch(RSP) on the Alzheimer’s disease.
Method:The effects of RSP on amyloid precursor proteins(APP), acetylcholinesterase (AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 cell treated by amyloid ${\beta}$ protein$(A{\beta})$ and $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ mRNA of THP-1 cell treated by lipopolysaccharide(LPS), AChE activity of PC-12 cell lysate treated by $A{\beta}$ and behavior of the memory deficit mice induced by scopolamine, and glucose, AChE in serum of the memory deficit mice induced by scopolamine were investigated, respectively.
Result: 1. RSP suppressed APP, AChE, GFAP mRNA in PC-12 celt treated by $A{\beta}$. 2. RSP suppressed $IL-1{\beta}$, IL-6, $TNF-{\alpha}$ mRNA in THP-1 cell treated by LPS. 3. RSP suppressed AChE activity in cell lysate of PC-12 cell treated by $A{\beta}$. 4. RSP increased glucose and decreased AChE significantly in the serum of the memory deficit mice induced by scopolamine. 5. RSP group showed significantly inhibitory effect on the scopolamine-induced impairment of teaming and. memory in the experiment of Morris water maze.
Conclusion: According to the above results, it is suggested that RSP might be usefully applied for prevention and treatment of Alzheimer’s disease and memory deficit symptom.
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KEYWORD
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Alzheimer’s disease, Rhododendron simsii Planch(RSP)
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